Reduction Mappings between Probabilistic Boolean Networks

نویسندگان

  • Ivan Ivanov
  • Edward R. Dougherty
چکیده

Probabilistic Boolean networks (PBNs) comprise a model describing a directed graph with rule-based dependences between its nodes. The rules are selected, based on a given probability distribution which provides a flexibility when dealing with the uncertainty which is typical for genetic regulatory networks. Given the computational complexity of the model, the characterization of mappings reducing the size of a given PBN becomes a critical issue. Mappings between PBNs are important also from a theoretical point of view. They provide means for developing a better understanding about the dynamics of PBNs. This paper considers two kinds of mappings reduction and projection and their effect on the original probability structure of a given PBN.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Mappings between probabilistic Boolean networks

Probabilistic Boolean Networks (PBNs) comprise a graphical model based on uncertain rule-based dependencies between nodes and have been proposed as a model for genetic regulatory networks. As with any algebraic structure, the characterization of important mappings between PBNs is critical for both theory and application. This paper treats the construction of mappings to alter PBN structure whil...

متن کامل

Boolean Models of Genomic Regulatory Networks: Reduction Mappings, Inference, and External Control

Computational modeling of genomic regulation has become an important focus of systems biology and genomic signal processing for the past several years. It holds the promise to uncover both the structure and dynamical properties of the complex gene, protein or metabolic networks responsible for the cell functioning in various contexts and regimes. This, in turn, will lead to the development of o...

متن کامل

Probabilistic Boolean Networks - The Modeling and Control of Gene Regulatory Networks

probabilistic boolean networks the modeling and control of probabilistic boolean networks the modeling and control of probabilistic boolean networks: the modeling and control probabilistic boolean networks society for industrial probabilistic boolean networks the modeling and control of probabilistic control of boolean networks with multiple from boolean to probabilistic boolean networks as mod...

متن کامل

Probabilistic Ontological Data Exchange with Bayesian Networks

We study the problem of exchanging probabilistic data between ontology-based probabilistic databases. The probabilities of the probabilistic source databases are compactly encoded via Boolean formulas with the variables adhering to the dependencies imposed by a Bayesian network, which are closely related to the management of provenance. For the ontologies and the ontology mappings, we consider ...

متن کامل

Intervention in Context-Sensitive Probabilistic Boolean Networks Revisited

An approximate representation for the state space of a context-sensitive probabilistic Boolean network has previously been proposed and utilized to devise therapeutic intervention strategies. Whereas the full state of a context-sensitive probabilistic Boolean network is specified by an ordered pair composed of a network context and a gene-activity profile, this approximate representation collap...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • EURASIP J. Adv. Sig. Proc.

دوره 2004  شماره 

صفحات  -

تاریخ انتشار 2004